Bonotide 750mcg Injection is a man-made version of parathyroid hormone used to treat men and postmenopausal women who have severe osteoporosis with a high risk of fractures. It works by stimulating new bone formation, which improves bone density and decreases the risk of spinal fractures.

Bonotide 750mcg Injection should be injected under the skin or given by a healthcare professional. You should use it regularly and at the same time each day to get the maximum benefit from it. Usually, it is recommended to take it for a maximum period of 2 years. However, follow the doctor’s advice and complete the course even if you feel better. It should be stored in the refrigerator at a temperature of 2°C to 8°C.

Some common side effects of this medicine include joint pain, injection site reactions (such as pain, swelling, and redness) and leg cramps. consult with your doctor if any of these bother you or do not go away.

Before taking this medicine, let your doctor know if you have kidney stones or any other kidney problems, as it can cause an increase in the amount of calcium in blood or urine. Pregnant and breastfeeding mothers should also consult with their doctors before taking this medicine. Your doctor may advise a bone scan to monitor the progress of your treatment.

Uses of Bonotide Injection

Osteoporosis

Benefits of Bonotide Injection

In Osteoporosis

Osteoporosis is a common condition that weakens bones, making them fragile and more likely to break. Bonotide 750mcg Injection helps treat osteoporosis in men as well as in women after menopause. It slows down the rate at which bone is broken down in your body. This maintains bone density and reduces your risk of breaking a bone. The injection is given by a doctor or nurse and should not be self-administered. You can help improve the strength of your bones by doing regular exercise (especially weight-bearing exercise), eating healthy foods containing calcium and Vitamin D and reducing your consumption of alcohol and tobacco. Supplements of calcium and Vitamin D3 are also effective.

Side effects of Bonotide Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Bonotide

Joint pain
Injection site reactions (pain, swelling, redness)
Nausea
Leg cramps

How to use Bonotide Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Bonotide Injection works

Bonotide 750mcg Injection is a synthetic form of a natural human hormone called parathyroid hormone (PTH). It works by increasing the number and activity of bone-forming cells (osteoblasts). This strengthens the bones and minimizes the risk of fractures.

Safety advice

Alcohol

CAUTION

Caution is advised when consuming alcohol with Bonotide 750mcg Injection. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Bonotide 750mcg Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Bonotide 750mcg Injection during breastfeeding is not available. Please consult your doctor.

Driving

UNSAFE

Bonotide 750mcg Injection may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Bonotide 750mcg Injection should be used with caution in patients with kidney disease. Dose adjustment of Bonotide 750mcg Injection may be needed. Please consult your doctor.
Use of Bonotide 750mcg Injection is not recommended in patients with severe kidney disease.

Liver

CONSULT YOUR DOCTOR

There is limited information available on the use of Bonotide 750mcg Injection in patients with liver disease. Please consult your doctor.

What if you forget to take Bonotide Injection?

If you miss a dose of Bonotide 750mcg Injection, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.\n

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Bonotide 750mcg Injection

₹66.0/Injection

Terifrac Injection

Intas Pharmaceuticals Ltd

₹5500/injection

8233% costlier

Zotide Injection

Cipla Ltd

₹8893/injection

13374% costlier

Osteofrac 750mcg Injection

Intas Pharmaceuticals Ltd

₹8175/injection

12286% costlier

Bonrange-PTH Injection

Biorange Biologicals Private Limited

₹9500/injection

14294% costlier

Terifrac Injection (3ml Each)

Intas Pharmaceuticals Ltd

₹13955/injection

21044% costlier

Quick tips

Bonotide 750mcg Injection should be injected every day under the skin (subcutaneous injection) of the thigh or abdomen.
Do not take it for more than 2 years.
You may have low blood pressure and dizziness during the initial few days.
If you feel dizzy (light-headed) after injection, sit or lie down until you feel better.
Tell your doctor immediately if you experience nausea, vomiting, constipation, low energy, or muscle weakness. These may be signs of high calcium levels in your blood.
Tell your doctor if you are breastfeeding, pregnant or plan to become pregnant.

Fact Box

Chemical Class

Parathyroid Hormone Analogs

Habit Forming

Therapeutic Class

HORMONES

Action Class

Bone formation stimulator -PTH analogue

Patient concerns

Teriparatide is this injection advisable?

Dr. Akshat Goel

Orthopaedics

Yes, it's good in Osteoporosis

Details About osteoporosis treatment

Dr. Akshat Goel

Orthopaedics

Take Calcium and Vitamin-D3 supplements

Is Bonotide 750mcg Injection a steroid?

No, Bonotide 750mcg Injection is not a steroid. However, this medicine may be used to treat osteoporosis caused by long-term use of steroids. Generally, this medicine is used to treat osteoporosis in women of postmenopausal age group and in men who have increased risk of fracture.

Can I take this medication in long term for osteoporosis?

Bonotide 750mcg Injection should not be taken for longer than 2-year course. It is important to inform the doctor if you have taken this medication in the past, as you should not receive more than one treatment of 24 months course more than once in your lifetime.

How is Bonotide 750mcg Injection stored at home?

Always keep this medicine stored in a refrigerator at a temperature of about 2°C to 8°C. Be cautious, the temperature should not decrease further as freezing may cause the medicine to get damaged and can lead to loss of activity. Therefore, avoid placing the Bonotide 750mcg Injection pens close to the ice compartment of the refrigerator. If properly stored this medication can be used up to 28 days after the first injection. If the pen is not empty within 28 days please discard it safely.

Who should not use Bonotide 750mcg Injection?

The doctor will decide whether the medicine is required for a patient or not. There are few conditions in which the use of Bonotide 750mcg Injection should be avoided such as in patients with kidney impairment, Paget’s disease, any type of bone cancers or unexplained high levels of serum calcium. It should also be avoided by children, young adult or growing age, pregnant or lactating females. Hence, before starting the medication inform the doctor about any medical condition and the medication you are taking. This will help the doctor to design a proper therapy for you.

Related lab tests

Calcium

Related ayurvedic ingredients

Fish Oil

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Bikle DD. Agents That Affects Bone Mineral Homoestasis. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 766.
Friedman PA. Agents Affecting Mineral Ion Homeostasis and Bone Turnover. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1300
Teriparatide. Indianapolis, Indiana: Lilly France; 2008. [Accessed 02 Apr. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 02 Apr. 2019] (online) Available from:

Country of origin: India

The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.