Imatikast 400mg Tablet is used to treat several types of cancers. It is most commonly prescribed to treat blood cancers (chronic myeloid leukemia and acute lymphocytic leukemia) and gastrointestinal stromal tumors. It works by targeting specific proteins that contribute to the growth and spread of cancer cells.

Imatikast 400mg Tablet is used to treat different types of cancer

Uses of Imatikast Tablet

Treatment of Cancer

Benefits of Imatikast Tablet

In Treatment of Cancer

In several types of cancers like blood cancers, gastrointestinal stromal tumors, skin cancer (dermatofibrosarcoma protuberans), and bone marrow condition (aggressive systemic mastocytosis), Imatikast 400mg Tablet targets the specific proteins that contribute to the growth and spread of cancer cells. By stopping these proteins, the medicine slows down or even stops the growth of cancer. This helps shrink tumors, slow down their growth, and make the patients feel better.

Side effects of Imatikast Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Imatikast

Edema (swelling)
Nausea
Vomiting
Muscle cramp
Musculoskeletal (bone, muscle or joint) pain
Diarrhea
Rash
Fatigue
Abdominal pain
Bleeding
Breathing problems
Cough
Weight gain
Dry eye
Dizziness
Hemorrhage

How to use Imatikast Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Imatikast 400mg Tablet is to be taken with food.

How Imatikast Tablet works

Imatikast 400mg Tablet is an anti-cancer medication. A protein enzyme, bcr-abl tyrosine kinase, responsible for the growth of abnormal proliferation of cancer cells. This medicine inhibits the proliferation and induces apoptosis (planned cell death) in bcr-abl positive cells (cancer cells). This is how it works to stop or slow the spread of cancer.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Imatikast 400mg Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Imatikast 400mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Imatikast 400mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Lactating women should not breastfeed while using this drug and 15 days after stopping it.

Driving

UNSAFE

Imatikast 400mg Tablet may cause side effects which could affect your ability to drive.

Kidney

CAUTION

Imatikast 400mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Imatikast 400mg Tablet may be needed. Please consult your doctor.

Liver

CAUTION

Imatikast 400mg Tablet should be used with caution in patients with severe liver disease. Dose adjustment of Imatikast 400mg Tablet may be needed. Please consult your doctor.

What if you forget to take Imatikast Tablet?

If you miss a dose of Imatikast 400mg Tablet, skip it and continue with your normal schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Imatikast 400mg Tablet

₹230.0/Tablet

Veenat 400 Tablet

Natco Pharma Ltd

₹202.7/tablet

4% cheaper

Imatib 400 Tablet

Cipla Ltd

₹153.51/tablet

27% cheaper

Imat 400 Tablet

Biochem Pharmaceutical Industries

₹184.91/tablet

13% cheaper

Glivec 400mg Tablet

Novartis India Ltd

₹238/tablet

12% costlier

Lupinib 400 Tablet

Lupin Ltd

₹216.13/tablet

2% costlier

View all substitutes

Quick tips

Always take it with food and a full glass of water to prevent nausea.
It may cause dizziness or blurred vision. Do not drive or do anything requiring concentration until you know how it affects you.
Water retention and swelling are very common side effects of Imatikast 400mg Tablet. Notify your doctor if you have unexpected rapid weight gain.
Do not change the dose or discontinue use without consulting your doctor.
Notify your doctor about all the medications you are taking, including over the counter medicines and dietary supplements.
Your doctor may get regular blood tests done to monitor your liver function and the number of blood cells in your blood.

Fact Box

Chemical Class

Benzanilides Derivative

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Tyrosine kinase inhibitors

Patient concerns

How we can find out parient is CA and which report we can do for know the patient is CA

Dr. Sanjay Singh Rai

Medical Oncology and Hematology

Thr is no single test for cancerWhich cancer ur looking for

Sir my brother have skin cancer can you do something for save his life ??

Dr. Sanjay Singh Rai

Medical Oncology and Hematology

Treatment of cancer depends on whether it is localized or metastatic cancer

Smears show metastatic mucinous adenocarcinoma.HISTOPATHOLOGY REPORT.sir is there any treatment Sir my mom firstly suffered from stomach pain.Then say about doing ultra sound test which is as:Neoplasm Stomach Pylrus.Fresh blood in corpus .polypoid growth in pylrus biopy taken from HPE Sir please help doctors already said there is no treatment for this stomach cancer disease

Dr. Sanjay Singh Rai

Medical Oncology and Hematology

Cancer is treated based on stage of cancerPlease upload reports of Ultrasound and endoscopy

I want to know the symptoms of cancer as I am a smoker

Dr. Vijay Sharnangat

Medical Oncology and Hematology

Symptoms for cancer depends upon which organ involved. For smokers , definitely chronic , they have possibility to develop lung cancer, head and neck cancers, oesophagus cancer, pancreatic cancer, stomach cancer and so more on. General symptoms would be like loss of appetite, weight loss, low grade fever in some cases, chronic cough for long time.

FAQs

Can Imatikast 400mg Tablet be taken with food?

Yes, the best way to take it is with a glass of water and food. This prevents irritation in the food pipe and stomach. If you cannot swallow it, put the tablets in a glass of water or apple juice (approximately 50 ml for a 100 mg tablet and 200 ml for a 400 mg tablet). Stir it with a spoon to make it uniform and drink it immediately.

Is it safe to drive while taking Imatikast 400mg Tablet?

Imatikast 400mg Tablet may cause dizziness, lightheadedness or drowsiness in some people. Make sure you know how you react to it before you drive a car or operate machinery.

What precautions need to be followed while taking Imatikast 400mg Tablet?

While taking Imatikast 400mg Tablet, make sure you follow all the instructions given by your doctor, carefully and keep all appointments. You will need regular follow-up to ensure that the treatment is working. Regular blood tests, weight checks, and urine tests may be required to find out any side effects before it becomes serious. Make sure you use a method of contraception to prevent pregnancy during treatment with Imatikast 400mg Tablet. Tell your doctor immediately if you become pregnant while you are taking this medicine. If you are about to start taking any new medicine, remind your doctor that you are taking Imatikast 400mg Tablet.

Ever since I started using Imatikast 400mg Tablet, I have noticed that I develop rashes and severe itching when I have sun exposure. Is it because of the medicine or the disease?

This medicine may make your skin much more sensitive to sunlight than it normally is. Exposure to sunlight may cause skin rash, itching, redness or severe sunburn. When you are outdoors, wear protective clothing and use a sunscreen with an SPF of 15 or higher. If you feel a burning sensation on your skin, tell your doctor.

The doctor has advised me not to take any medicine on my own while taking Imatikast 400mg Tablet. Should I consult my doctor even if I need to take paracetamol for my fever?

Yes, there are a number of medicines which interfere with Imatikast 400mg Tablet, including paracetamol. Therefore you should not self medicate while taking Imatikast 400mg Tablet. Other medicines which interfere with Imatikast 400mg Tablet include cyclosporin, dexamethasone (a steroid), warfarin, antiviral medicines which treat AIDS and some medicines which treat bacterial infections, high cholesterol, high blood pressure, heart problems, and mental disorders and depression. Consult your doctor before taking any medicine, and inform him that you are on Imatikast 400mg Tablet therapy.

Can I expect that if I take Imatikast 400mg Tablet regularly and as advised by the doctor for CML, I will be cured?

Imatikast 400mg Tablet has proved effective in many cases of CML. It is also noticed that the chances of survival increase after taking this medicine. The doctor who is treating CML can tell you better. The doctor will analyze your current state, blood test results, response to treatment, any other medical illness which you may be having, etc. and tell you.

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Chabner BA, Barnes J, Neal J, et al. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1732-34.
Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 953.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 692-94.
Imatinib mesylate. East Hanover, New Jersey: Novartis Pharmaceuticals Corporation; 2001 [revised Jan 2012]. [Accessed 23 Jan. 2019] (online) Available from:
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Imatinib. [Updated 2018 Oct 31]. [Accessed 18 Feb. 2020] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 26 Mar. 2019] (online) Available from:
Natco Pharma Limited. Safety Data Sheet: Imatinib Mesylate. 2019. [Accessed 05 Jul. 2023]. (online) Available from:
CiplaMed. Imatinib mesylate [Prescribing Information]. [Last Revised: 26 Apr. 2021]. [Accessed 05 Jul. 2023]. (online) Available from:

Marketer details

Name: Aprazer Healthcare Pvt Ltd

Address: 36-B, Pusa Rd, Block 11, Old Rajinder Nagar, Rajinder Nagar, New Delhi, Delhi 110060

Country of origin: India

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