Isoniazid 300mg Tablet is an antibiotic used for the treatment and prevention of tuberculosis (TB) and inactive (latent) TB (a serious infection caused by bacteria that affects the lungs and in certain cases other parts of the body). It works by killing the bacteria that cause tuberculosis.

It is an antibiotic.

Uses of Isoniazid Tablet

Tuberculosis (TB)

Benefits of Isoniazid Tablet

In Tuberculosis (TB)

Isoniazid 300mg Tablet is used to treat tuberculosis, an infectious disease that mainly affects the lungs but can affect other parts of the body as well. It kills and stops the growth of infection causing bacteria and helps in treating the infection. Take it in the dose and duration advised by the doctor. Your symptoms may improve before the infection is completely cured. Do not stop taking it without consulting your doctor as doing so may cause the infection to return or worsen. Follow your doctor’s instructions carefully to get maximum benefit.

Side effects of Isoniazid Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Isoniazid

Peripheral neuropathy (tingling and numbness of feet and hand)
Hepatitis (viral infection of liver)
Skin rash
Lethargy
Increased liver enzymes

How to use Isoniazid Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Isoniazid 300mg Tablet is to be taken empty stomach.
Avoid Isoniazid 300mg Tablet with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.

Safety advice

Alcohol

UNSAFE

Consuming alcohol while taking Isoniazid 300mg Tablet may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).

Pregnancy

CONSULT YOUR DOCTOR

Isoniazid 300mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

SAFE IF PRESCRIBED

Isoniazid 300mg Tablet is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.

Driving

UNSAFE

Isoniazid 300mg Tablet may cause side effects which could affect your ability to drive.
Isoniazid 300mg Tablet can cause fits, mental health problems and optic neuritis (inflammation of the optic nerve that may cause loss of vision.) This may affect your driving ability.

Kidney

SAFE IF PRESCRIBED

Isoniazid 300mg Tablet is safe to use in patients with kidney disease. No dose adjustment of Isoniazid 300mg Tablet is recommended.
However, talk to your doctor if you have any underlying kidney disease.

Liver

CAUTION

Isoniazid 300mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Isoniazid 300mg Tablet may be needed. Please consult your doctor.
Use of Isoniazid 300mg Tablet is not recommended in patients with severe liver disease.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Isoniazid 300mg Tablet

₹0.17/Tablet

Solonex Tablet

Macleods Pharmaceuticals Pvt Ltd

₹1.26/tablet

600% costlier

Lup Inh 300mg Tablet

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₹1.09/tablet

506% costlier

Isonij 300mg Tablet

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₹1.12/tablet

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Isonex 300mg Tablet

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₹2.15/tablet

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Quick tips

Your doctor has prescribed Isoniazid 300mg Tablet to cure your infection and improve symptoms.
It is best taken on an empty stomach.
You must also take a vitamin B6 supplement while on Isoniazid 300mg Tablet.
Tell your doctor immediately if you experience vision changes, loss of appetite, tiredness, stomach pain, nausea or vomiting, yellow skin or eyes or dark-colored urine.

Fact Box

Chemical Class

Nicotinic acid derivatives

Habit Forming

Therapeutic Class

ANTI INFECTIVES

Action Class

Mycolic acid inhibitors- INH

Patient concerns

I had ectopic pregnancy as advice by dr.I had gone for laparoscopy for my other tube and after dat she gave me this medication ISONIAZID, PYRAZINAMIDE 750mg,PYRICO TIN, COMBUTOL600 which I had checked online dis all tablets r for TB so should I continue or stop

Dr. Sonu Balhara Ahlawat

Obstetrics and Gynaecology

If u have been diagnosed with tuberculosis then start otherwise not

My daughter is given tb medicine even though she is not infected taking these medicine will cause tb???

Dr. Rahul Yadav

Paediatrics

Hello, TB medicines are given only when there is indication of tuberculosis. They are for treating tuberculosis.

User feedback

Patients taking Isoniazid 300mg Tablet

Once A Day

100%

What are you using Isoniazid Tablet for?

Tuberculosis *

80%

Others

20%

*Tuberculosis (TB)

How much was the improvement?

Poor

33%

Average

33%

Excellent

33%

What were the side-effects while using Isoniazid 300mg Tablet?

No Side Effec*

67%

Jaundice

33%

*No Side Effect

How do you take Isoniazid Tablet?

Empty stomach

100%

FAQs

Is Isoniazid 300mg Tablet an antibiotic?

Isoniazid 300mg Tablet is an antibiotic used in the prevention and treatment of tuberculosis or TB (a serious infection caused by bacteria that affects the lungs and in certain cases other parts of the body)

Is Isoniazid 300mg Tablet chemotherapy/chemotherapy drug?

Isoniazid 300mg Tablet is a primary antibiotic used for treatment of tuberculosis. Do not confuse it with chemotherapy or chemo drugs used for the treatment of cancer

Is Isoniazid 300mg Tablet bacteriostatic or bactericidal?

Isoniazid 300mg Tablet is a bacteriostatic antibiotic. It stops or suppresses growth of tuberculosis causing bacteria by interfering with the formation of protective outer covering (cell wall) which is essential for their growth

Is Isoniazid 300mg Tablet safe?

Yes. Isoniazid 300mg Tablet is safe if used at prescribed doses for the prescribed duration as advised by your doctor

Is Isoniazid 300mg Tablet a MAOI?

Isoniazid 300mg Tablet has very weak inhibitory activity on enzymes monoamine oxidases (MAO); however it is not used as a monoamine oxidase inhibitor (MAOI)

Is Isoniazid 300mg Tablet a sulfa drug?

No. The chemical structure and mechanism of action of Isoniazid 300mg Tablet is different from sulfa drugs

Is Isoniazid 300mg Tablet an inducer or inhibitor?

Isoniazid 300mg Tablet is an inhibitor (decreases activity) of an important liver enzyme system that is responsible for the final processing and elimination of several drugs from the body

Can I take isoniazid with ibuprofen/Benadryl/Nyquil/Aleve/Mucinex/amoxicillin?

There no known serious drug interactions of isoniazid with ibuprofen, paracetamol (trade name: Tylenol), naproxen (trade name: Aleve), amoxicillin or any active drug present in Nyquil or Mucinex. Please inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects

Does Isoniazid 300mg Tablet cause weight loss/weight gain/hair loss/diarrhea/affect menstruation?

Changes in body weight (gain/loss), hair loss, diarrhea or changes in menstruation are not among the known side effects of Isoniazid 300mg Tablet. You may experience few of these side effects while on multi drug (including Isoniazid 300mg Tablet) treatment for tuberculosis

Does Isoniazid 300mg Tablet cause acne/make you tired/cause constipation?

You may experience unusual tiredness, constipation or acne while on treatment with Isoniazid 300mg Tablet. Please inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects

Does Isoniazid 300mg Tablet affect birth control?

Isoniazid 300mg Tablet has no known interaction with commonly used oral contraceptives (birth control pills). However, multidrug treatment for tuberculosis contains active drug rifampin that decreases the effectiveness of oral contraceptives and hampers birth control.

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Related lab tests

Complete Blood Count

Erythrocyte Sedimentation Rate

Mycobacterium Tuberculosis DNA PCR - Qualitative

Peripheral Smear Examination

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Gumbo T. Chemotherapy of Tuberculosis, Mycobacterium Avium Complex Disease, and Leprosy. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1555-558.
Chambers HF, Deck DH. Antimycobacterial Drugs. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 824-25.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 741-42.
Isoniazid. Nottingham, Nottinghamshire: Boots Contract Manufacturing; 2015. [Accessed 01 Apr. 2019] (online) Available from:
Drugs.com. Isoniazid. [Accessed 01 Apr. 2019] (online) Available from:
Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 29 Mar. 2019] (online) Available from:

Marketer details

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Address: Sarkhej-Dholka Road, Bhat, Ahmedabad-382 210, INDIA.

Country of origin: India

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