Home›Coagulation Profile (PT/INR & aPTT)

Content created by

Written by

BDS, MDS - Oral and Maxillofacial Pathology

Reviewed by

Dr. Ashish Ranjan

MBBS, MD (Pharmacology)

Want to know more?
Read our Editorial Policy

Coagulation Profile (PT/INR & aPTT)

Coagulation Profile (PT/INR & aPTT) Includes 2 testsView All

₹860

This test is for

Male, Female

Understanding Coagulation Profile (PT/INR & aPTT)

What is Coagulation Profile (PT/INR & aPTT)?

Coagulation profile helps to determine the concentration of coagulation factors in the blood. It helps to assess the blood's ability to dissolve a clot as well as its clotting time. It is useful for evaluating the risk of excessive bleeding or developing clots (thrombosis).This profile includes two tests, Activated Partial Thromboplastin Time test and Prothrombin Time test.
This profile is recommended for the diagnosis of bleeding or clotting disorders, before a surgery, to patients undergoing the treatment for these diseases.
It is also suggested as a screening test before conceiving to mitigate the risk of birth defects in a baby.

What is Coagulation Profile (PT/INR & aPTT) used for?

Coagulation Profile is done:

In case of excessive unexplained bleeding
In case of easy bruising
In acute conditions such as Disseminated intravascular coagulation
In chronic conditions such as liver disease
To monitor the patients taking medicines affecting clotting ability
Before surgery

Interpreting Coagulation Profile (PT/INR & aPTT) results

Interpretations

Prothrombin time: 11 s - 15 s

Activated partial thromboplastin time: 25 s - 35 s

Reference range may vary from lab to lab*

Results of PT	Results of PTT	Can be seen in the following conditions
Prolonged	Normal	Diseases of liver, Vitamin K deficiency, Defective factor VII, Chronic disseminated intravascular coagulation
Normal	Prolonged	Hemophilia A or B, Factor XI deficiency, Von Willebrand disease, Factor XII deficiency, Presence of lupus anticoagulant
Prolonged	Prolonged	Defective factor I, II, V or X, Severe liver disease, Acute disseminated intravascular coagulation

Answers to Patient Concerns & Frequently Asked Questions (FAQs) about Coagulation Profile (PT/INR & aPTT)

Frequently Asked Questions about Coagulation Profile (PT/INR & aPTT)

Q. How is the blood sample taken?

The healthcare provider takes a blood sample from the arm. The site from where the blood is to be withdrawn is cleaned with a swab of rubbing alcohol. This is then followed by inserting a small needle which has a tube attached to it for collecting blood. Once the sufficient blood for analysis is withdrawn, the needle is removed. The site is then covered with a gauze pad.

Q. In what conditions can shortened PTT be seen?

Shortened PTT can be seen in case of disseminated intravascular coagulation, advanced stages of cancer, and acute phase reactions.

Q. What other tests can be advised by the doctor in case of abnormal coagulation profile?

In case of abnormal coagulation profile, the doctor can advise platelet count, thrombin time, fibrinogen testing, coagulation factor tests, lupus anticoagulant testing, and test for von Willebrand factor.

Q. Is there any risk associated with the withdrawal of blood sample procedure?

As such there is no risk but in few cases, bruising, bleeding, and infection at the puncture site can be seen. In very few cases, there can be swelling of the vein after the blood is withdrawn.

Q. What conditions can cause coagulation disorders?

Coagulation disorders could be due to conditions such as liver disease, thrombophilia, and hemophilia.

+ more