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Understanding the Test
Test Measures
FAQ's
References
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Arthritis Profile

Also known as Arthritis panel
Arthritis Profile Includes 5 testsView All
You need to provide
Blood
This test is for
Male, Female
Test Preparation
  1. Overnight fasting is preferred but not mandatory.

Understanding Arthritis Profile


What is Arthritis Profile?

An Arthritis Profile tells about the severity and type of arthritis, a condition characterized by inflammation and stiffness in one or more joints. This test includes various blood markers that help in the diagnosis and treatment planning of arthritis.

Arthritis, a common yet complex group of musculoskeletal disorders can lead to debilitating pain, stiffness, and impaired mobility. Given its diverse manifestations and underlying causes, an accurate diagnosis is paramount for effective management and targeted treatment strategies. 

An Arthritis Profile helps in the diagnosis, management, and monitoring of arthritis and related conditions. It includes various laboratory tests to assess inflammatory markers, autoimmune antibodies, and specific biomarkers associated with different types of arthritis. These may include tests such as C-reactive protein (CRP) and rheumatoid factor (RF). These tests help differentiate between different types of arthritis, such as rheumatoid arthritis, osteoarthritis, psoriatic arthritis, and gout, among others, guiding doctors toward an accurate diagnosis. The information obtained from this test enables doctors to formulate personalized treatment plans tailored to your specific type of arthritis, its severity, and treatment goals. 

Early detection is key to successful arthritis management, as it can help prevent joint damage, improve quality of life, and reduce the risk of long-term complications. Risk factors such as age, genetics, obesity, and previous joint injuries play a role in arthritis development, but preventive measures such as maintaining a healthy weight, regular exercise, and avoiding repetitive joint stressors can help mitigate these risks. 

Usually, overnight fasting (8-12 hours) is preferred before going for an Arthritis Profile. However, drinking water is acceptable. It is important to inform the doctor if you are taking other medications or supplements as they might interfere with test results, necessitating temporary cessation. 

Lab test results may vary across different laboratories. Abnormal test results require an expert interpretation, therefore, never try to self-medicate at home based solely on these results, and always consult a doctor for proper understanding of the test results. Discuss your symptoms and medical history to help the doctor correlate your clinical and laboratory findings, leading to a more accurate diagnosis and effective treatment plan tailored to your specific health needs. Your doctor may suggest lifestyle modifications, including dietary changes, stress management techniques, and ergonomics adjustments for arthritis management. Regular monitoring and follow-up appointments are crucial for tracking disease progression, adjusting treatment plans as needed, and addressing any new symptoms or concerns. 

What is Arthritis Profile used for?

An Arthritis Profile is done: 

  • To facilitate early detection of arthritis, potentially preventing joint damage and improving long-term outcomes.
  • To identify the type and severity of arthritis.
  • To differentiate between various types of arthritis.
  • To track arthritis progression and treatment response over time.
  • To test for autoimmune antibodies like rheumatoid factor (RF) to detect autoimmune-related conditions.
  • To assess specific biomarkers associated with arthritis to guide diagnosis and treatment
  • To help identify individuals at risk of developing arthritis or experiencing disease manifestations. 
  • In individuals with risk factors like a family history of arthritis, obesity, etc.
  • To assess overall joint health and inflammation in the body. 

What does Arthritis Profile measure?

Contains 5 tests

An Arthritis Profile measures various biomarkers related to joint health and inflammation, telling about the type and severity of arthritis. This comprehensive assessment includes tests for inflammatory markers such as C-reactive protein (CRP), which indicates the presence and extent of inflammation in the body. Elevated CRP levels are commonly associated with arthritis and help doctors understand disease activity and monitor treatment effectiveness. Additionally, this profile includes tests for autoimmune antibodies like rheumatoid factor (RF), which are indicative of autoimmune-related arthritis such as rheumatoid arthritis. Detecting these antibodies helps in differentiating between different types of arthritis and guiding treatment decisions. Moreover, An Arthritis Profile evaluates specific biomarkers associated with arthritis, helping in diagnosis and personalized treatment planning. For example, measuring serum calcium and phosphorous levels helps assess bone health, crucial in conditions like osteoarthritis and osteoporosis. Furthermore, the profile includes uric acid testing which helps diagnose and monitor gout, a type of arthritis caused by the accumulation of urate crystals in the joints. By analyzing these biomarkers collectively, doctors can gain a comprehensive understanding of your joint health, inflammation levels, and disease status, helping them formulate tailored treatment plans aimed at improving symptoms and preserving joint function. 

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Serum Calcium

The Serum Calcium test measures the levels of calcium in the body. Calcium is the most abundant mineral in the body; most of it is present in the bones and teeth, and the remaining portion (around 1%) is found in the blood. It is usually present in two forms in blood in about equal amounts: "bound calcium," which is attached to proteins in the blood, and "free calcium or ionized calcium," which is not attached to any protein. 

The Serum Calcium test cannot be used to check for lack of calcium in your diet or osteoporosis (loss of calcium from bones) as the body can have normal calcium levels even in dietary calcium deficiency. Moreover, the body can normalize mild calcium deficiency by releasing the calcium stored in bones.

Know more about Serum Calcium

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Phosphorus, Serum

The Phosphorus, Serum test is used to evaluate the level of phosphorus in your blood. Phosphorus is an inherent component of all living cells in the system and most, 85 percent, is located in the tissues of bones and teeth, while the remaining 15 percent is part of the blood and other soft tissues. Your body obtains its daily phosphorus requirements through dietary sources and under normal conditions, once the necessary amounts of phosphorus are absorbed by the cells and tissues, the remaining is eliminated via the urine.

Besides consuming a wholesome diet enriched with sufficient amounts of phosphorus, it is also important to ensure ample intake of calcium and vitamin D, to maintain overall health.

 

Know more about Phosphorus, Serum

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Uric Acid

An Uric Acid test determines the level of uric acid in your body. Uric acid is a nitrogenous compound produced by the metabolic breakdown of purine. Purines are present as nitrogenous bases in the DNA and are also found in food like red meat and seafood.

Most uric acid dissolves in the blood and goes into your kidneys. From there, it passes through your body via the urine. Decreased elimination of uric acid is often a result of impaired kidney function due to kidney disease. In many cases, the exact cause of excess uric acid is unknown. Doctors seldom need to test for low levels of uric acid.

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CRP (C-Reactive Protein), Quantitative

The CRP test measures the levels of C-reactive protein in your body. This test helps detect the presence of inflammation in the body. It is a non-specific test as it cannot diagnose a condition by itself or determine its exact location or cause. 

CRP is an acute phase reactant protein produced by the liver in response to an inflammation in the body. This inflammation may be due to tissue injury, infection, autoimmune diseases, or cancer. CRP levels are often increased before the onset of other symptoms of inflammation, such as pain, redness, fever, or swelling. These levels fall as the inflammation subsides.

Know more about CRP (C-Reactive Protein), Quantitative

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Rheumatoid Factor - Quantitative

The Rheumatoid Factor - Quantitative test detects and measures the concentration of rheumatoid factor (RF), an antibody produced by the immune system, in your blood. Increased levels of rheumatoid factor can be detected in the blood in certain autoimmune conditions, particularly rheumatoid arthritis. However, an RF test is not very specific as a rheumatoid factor can also be found in the body in diseases other than RA, such as Sjögren’s syndrome and systemic lupus erythematosus (SLE). RF may also be produced in the body during persistent bacterial and viral infections. Hence, clinical evaluation and other diagnostic tests are crucial for a comprehensive assessment and accurate diagnosis.

Know more about Rheumatoid Factor - Quantitative

Answers to Patient Concerns & Frequently Asked Questions (FAQs) about Arthritis Profile


Frequently Asked Questions about Arthritis Profile

Q. Why is an Arthritis Profile important?

An Arthritis Profile is important because it tells about the type, severity, and underlying causes of arthritis. It includes various tests to assess inflammation levels, autoimmune activity, and specific biomarkers associated with different types of arthritis. This comprehensive evaluation guides doctors in making accurate diagnosis, formulating personalized treatment plans , and monitoring disease progression over time.

Q. Who should consider getting an Arthritis Profile?

Individuals experiencing joint pain, stiffness, and swelling and those at risk of developing arthritis due to family history or other risk factors should consider getting Arthritis Profile.

Q. How is an Arthritis Profile performed?

A phlebotomist (a trained professional to perform blood draws) will clean your skin using an antiseptic alcohol cotton swab or wipe and take blood samples from your vein using a needle. The blood sample will be stored safely and transported to the laboratory for analysis.

Q. Is there any risk associated with an Arthritis Profile?

No, an Arthritis Profile is generally safe with minimal risks. However, you may feel slight discomfort during blood sample collection but chances of serious complications are extremely rare.

Q. How often should an Arthritis Profile be done?

The frequency depends on individual circumstances, including whether a person has been diagnosed with arthritis or has risk factors for the disease.

Q. Can arthritis be cured?

There is no cure for arthritis but your doctor will help you find treatments that manage your symptoms.

Q. Is arthritis hereditary?

Some forms of arthritis, such as rheumatoid arthritis can be hereditary and run in families.

Q. Is arthritis only a disease of the elderly?

No, arthritis can affect individuals of all ages, though some types are more common in older adults.
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References

  1. Senthelal S, Li J, Ardeshirzadeh S, et al. Arthritis. [Updated 2023 Jun 20]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK518992/ External Link
  2. Arthritis [Internet]. National Institute of Health: Bethesda, MD; 2023 November 16 [Accessed 26 Mar. 2024]. Available from: https://www.nih.gov/about-nih/what-we-do/nih-turning-discovery-into-health/research-healthy-living/arthritis External Link
  3. Chauhan K, Jandu JS, Brent LH, et al. Rheumatoid Arthritis. [Updated 2023 May 25]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK441999/ External Link
  4. Heidari B. Rheumatoid Arthritis: Early diagnosis and treatment outcomes. Caspian J Intern Med. 2011 Winter;2(1):161-70. PMID: 24024009; PMCID: PMC3766928. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766928/ External Link
  5. Suresh E. Diagnosis of early rheumatoid arthritis: what the non-specialist needs to know. J R Soc Med. 2004 Sep;97(9):421-4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1079582/ External Link
  6. Sen R, Hurley JA. Osteoarthritis. [Updated 2023 Feb 20]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482326/ External Link
  7. Tiwari V, Jandu JS, Bergman MJ. Rheumatoid Factor [Internet]. Treasure Island, Florida: StatPearls Publishing; Jan. 2023 [Accessed 26 Mar. 2024]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK532898/ External Link
  8. Rheumatoid Factor (Blood) [Internet]. Rochester, NY: University of Rochester Medical Center; [Accessed 26 Mar. 2024]. Available from: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=rheumatoid_factorExternal Link
  9. Rheumatoid Arthritis [Internet]. Atlanta, Georgia: Arthritis Foundation; 15 Oct. 2021 [Accessed 26 Mar. 2024]. Available from: https://www.arthritis.org/diseases/rheumatoid-arthritisExternal Link
  10. Rheumatoid Factor - an overview [Internet]. ScienceDirect; [Accessed 26 Mar. 2024]. Available from: https://www.sciencedirect.com/topics/medicine-and-dentistry/rheumatoid-factorExternal Link
  11. Rheumatoid arthritis (RA) [Internet]. CDC; 27 Jul. 2020 [Accessed 26 Mar. 2024]. Available from: https://www.cdc.gov/arthritis/basics/rheumatoid-arthritis.html External Link
  12. Ma CA, Leung YY. Exploring the Link between Uric Acid and Osteoarthritis. Front Med (Lausanne). 2017 Dec 13;4:225. [Accessed 26 Mar. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733531/#:~:text=Gout%20is%20a%20crystal%2Dinduced,elderly%20population%20worldwide%20(5). External Link
  13. Ashai S, Harvey NC. Rheumatoid arthritis and bone health. Clin Med (Lond). 2020 Nov;20(6):565-567. doi: 10.7861/clinmed.20.6.rabh. PMID: 33199321; PMCID: PMC7687316. [Accessed 04 Apr. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687316/ External Link

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