SGPT
Understanding SGPT
What is SGPT?
An SGPT test measures the amount of serum glutamate pyruvate transaminase (SGPT) enzyme in the blood. This test helps detect liver diseases, such as jaundice, hepatitis, liver cirrhosis, etc. It may be done as part of a routine health checkup or liver function test to detect possible liver damage or disease.
SGPT, also known as alanine transaminase (ALT) is an enzyme produced by the liver and has various functions. When the liver is damaged or inflamed due to certain medical conditions or lifestyle factors, it releases the enzyme ALT into the bloodstream. The SGPT/ALT test measures the level of this enzyme in your blood. Apart from the liver, ALT is also found in other parts of the body, such as the kidneys.
An SGPT/ALT test may be done if you experience symptoms such as loss of appetite, stomach pain, nausea, vomiting, itching, and the yellowing of the skin and eyes (symptoms of jaundice). This test may also help to monitor any ongoing liver disorders or evaluate the side effects of certain medicines affecting liver health and function; however, it does not tell the extent of liver damage. Usually, no special preparation is required for an SGPT/ALT test. You may eat and drink normally as per your daily routine.
Test result ranges are approximate and may differ slightly between labs depending on the methodology and laboratory guidelines. Talk to your doctor about your specific test results. Narrate your complete medical history to help the doctor correlate your clinical and laboratory findings. The test results will help them determine your medical condition, make recommendations for lifestyle modifications such as diet and exercise, decide whether or not medication will be required to manage your liver health and formulate your overall treatment plan.
What is SGPT used for?
An SGPT is done:
- As part of routine health checkups.
- As part of a liver function test.
- To help detect liver diseases, such as jaundice, liver cirrhosis, and non-alcoholic fatty liver disease.
- To monitor an existing liver disease and its treatment response.
- To help detect liver damage due to medicines like erythromycin, amiodarone, methyldopa, or amoxicillin-clavulanate.
- To evaluate liver health in conditions such as hepatitis infection.
- To check liver damage due to excessive alcohol consumption.
What does SGPT measure?
An SGPT test measures the amount of ALT or SGPT enzyme in your blood. ALT is most abundantly found in the liver, but it is also present in smaller amounts in other organs like the kidneys, heart, and muscles. Its primary function is to convert food into energy. It also speeds up chemical reactions in the body. These chemical reactions include the production of bile and substances that help your blood clot, break down food and toxins, and fight off an infection.
Elevated levels of ALT in the blood may indicate liver damage or injury. When the liver cells are damaged, they release ALT into the bloodstream, causing an increase in ALT levels. Therefore, the SGPT/ALT test is primarily used to assess the health of the liver and to detect liver-related problems such as hepatitis, fatty liver disease, cirrhosis, or other liver disorders.
Interpreting SGPT results
Interpretations
ALT (SGPT), Serum < 50 U/L
The reference range may vary from lab to lab*
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Very high ALT levels (more than 10 times normal) are usually due to acute hepatitis which is generally caused due to a viral infection
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High ALT levels (four times normal) may be seen in chronic hepatitis, obstruction of bile ducts, or cirrhosis
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In most liver diseases, the ALT level is higher than AST and the AST/ALT ratio will be low (less than 1). The AST/ALT ratio is greater than 1 in alcoholic hepatitis, cirrhosis, heart or muscle injury
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ALT is more specific than AST for liver disease