Secrin R

Glibenclamide + Metformin + Pioglitazone is a combination of three antidiabetic medicines: Glibenclamide + Metformin + Pioglitazone1, Glibenclamide + Metformin + Pioglitazone2 and Glibenclamide + Metformin + Pioglitazone3. They work by different mechanisms to provide better control of blood sugar when single or dual therapy is not effective. Glibenclamide + Metformin + Pioglitazone1 is a sulfonylurea which works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Glibenclamide + Metformin + Pioglitazone2 is a biguanide. It works by lowering glucose production in the liver, delaying glucose absorption from intestines and increasing the body's sensitivity to insulin. Glibenclamide + Metformin + Pioglitazone3 is a thiazolidinedione which further increases insulin sensitivity.